Football is just two days away, so it's about time you start locking in your Week 1 picks. The opening week of the NFL regular season is either one of the most fun gambling weeks of the year, or one you want to avoid -- depending on how you look at it. There are no past games to go off of, all the trends sharps examine are from last year and there are brand new players who will be experiencing their first action.There is always at least one big surprise. Take last year for example; the ' lone victory came in Week 1 against and the , and and the Washington Football Team beat the by double digits. There is no such thing as a "sure thing" in Week 1.Every year, we round up those on our CBS NFL roster and ask for their best bet for Week 1 of the regular season. Those taking part in this article are NFL insider Jonathan Jones, senior writer Pete Prisco, Pick Six Podcast host Will Brinson, plus writers John Breech, Ryan Wilson, Chris Trapa so, Jordan Dajani, Jared Dubin, Josh Edwards, Tyler Sullivan, Bryan DeArdo, Cody Benjamin and Jeff Kerr.First, we will list all 16 spreads and Over/Unders and then get into our best bets. Klay Thompson Jersey at (-7.5) (Over/Under 51.5) at (-3) (Over/Under 52) at (-5) (Over/Under 44.5) (-1) at Washington Football Team (Over/Under 44.5)Philadelphia Eagles at (-3.5) (Over/Under 48) (-2.5) at Indianapolis Colts (Over/Under 48.5) (-3) at (Over/Under 48)Jacksonville Jaguars (-3) at (Over/Under 44.5) at (-6.5) (Over/Under 48.5) (-7.5) at (Over/Under 45.5) (-2.5) at (Over/Under 42.5) at (-6) (Over/Under 53) at (-2.5) (Over/Under 44) (-4) at (Over/Under 50) at (-7.5) (Over/Under 44.5) (-4.5) at (Over/Under 51)Cowboys at BuccaneersPrisco: Cowboys +7.5.This line is bloated because the Bucs have all 22 starters back from the Super Bowl win. I get Rick Barry Jersey it. But let's not forget that team didn't even win the division. The Cowboys will stay in this game and lose by a field goal. Giving me 7.5 is an easy victory for the dog.Brinson: Buccaneers -7.5.It would be way too big a donkey move to buy a half a point here and make it -7 (-125) so I'm not going to do that and instead will just bank on the Buccaneers steam-rolling the Cowboys in the 2021 opener. is going through his first full offseason with the Buccaneers, who showed their potential on offense down the stretch last year once he really developed a rapport with his wide receivers. Everyone knows about Nate Thurmond Jersey the 22 starters coming back, so I won't rehash that. What I think is a little more interesting is the cohesion on the offensive line with all those guys coming back and the full health of on the interior of the defensive line. Young players like (legit DPOY candidate) and Antoine Winfield Jr. have even more seasoning now. The Cowboys defense might be better this year but I don't think it comes out strong in Week 1. And the Dallas offense wasn't great last year with a healthy . He's on track for Week 1 but this is a tough opening test. The Bucs roll in this one like 38-21. Breech: Buccaneers -7.5.Dak Prescott is coming off two injuries, he hasn't taken a game snap in 11 months and his first game is against one of the best defenses in football. This one might get ugly for the Cowboys.Cardinals at TitansSullivan: Cardinals +3.I don't love the way the Titans are trending heading into the regular season. Not only are they dealing with COVID-19 i sues, but both and have been dinged up throughout the summer. If they are le s than 100% out of the gate, and the Cardinals offense may have no problem leaving them in the dust. Tenne see has also struggled to begin the year historically. In their past five Week 1 contests, they are 1-4 ATS.49ers at LionsJones: 49ers -7.5.I gue s I understand that you can't make the spread too large in Week 1. But there's no evidence this Lions team will be able to keep pace with the Niners even if San Francisco isn't showing everything they have in the opener. This one seems obvious to me. (I also like Green Bay - Stephen Curry Jersey 3 against the Saints. Drew Brees isn't walking through that door.) Kerr: 49ers -7.5.The 49ers are one of the most talented teams in the NFL when healthy -- and have their full arsenal of players heading into this matchup. Detroit is rebuilding its roster under Dan Campbell -- and I'm unsure how the Lions are going to score 17 points against the 49ers defense. San Francisco should have its way against Detroit on the ground. This has the makings of a blowout.Dajani: 49ers -7.5.The 49ers are one of the biggest favorites in Week 1 and I'm jumping on board. With motivated to keep his job against a subpar opponent in the Lions, expect the 49ers to record a double-digit victory. Dubin: Under 45.5.I can't see the Lions scoring much and the Niners will be content to run the ball all game once they get a lead. Vikings at BengalsBenjamin: Vikings -3.5. return is exciting, but give me Mike Zimmer against his old flame here. The Bengals are still establishing their identity, and their secondary, while restocked, remains suspect. Minnesota can pound the ball on the ground, get after Burrow and take a nice road win to start the year.Dolphins at PatriotsWilson: Patriots -2.5.This New England team -- on both sides of the ball -- will look completely different from last year's 7-9 outfit. will be better in Year 2 but it's hard not to take Bill Belichick in that matchup.Broncos at GiantsTrapa so: Under 42.5.The Broncos defense is ready to rock again with and reunited on the edges and patrolling the deep middle. The Giants aren't stout defensively, but is one of the league's best big cornerbacks who should be a formidable matchup for in his first game back from an early 2020 injury. is a capable starter but not one accustomed to leading shootouts on the road. This will be your father's low-scoring battle. Packers at Saints (in Jacksonville)Edwards: Packers -4 Alen Smailagic Jersey .There are understandably going to be bigger concerns in the back of the minds of those on the Saints roster.Ravens at Raiders (MNF)DeArdo: Raiders +4.5.The Raiders may very well pull off the upset. Baltimore recently suffered a gut punch in losing for the season. Las Vegas is going to be riding the momentum of playing in front of fans at Allegiant Stadium for the first time