The encapsulated cell therapies and encapsulation technologies market is anticipated to evolve at a rapid pace over the

Roots Analysis has done a detailed study on Cell Encapsulation: Focus on Therapeutics and Technologies, 2019-2030, covering key aspects of the industry’s evolution and identifying potential future growth opportunities.

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Key Market Insights

Presently, over 45 encapsulated cell therapies and cell encapsulation techniques are being evaluated across different phases of development by stakeholders across the world
Ongoing therapy development programs are evaluating different types of cells, encapsulated in a wide range of biocompatible materials, aiming to offer viable and effective treatment options for various diseases
In fact, majority of the product candidates are being developed for the treatment of metabolic disorders, primarily diabetes; big pharma are driving a significant proportion of research and development activity
Clinical research in this field is growing at a fast pace; encapsulated therapy products are evaluating a number of pre-marketing end points to validate safety / efficacy
Over the years, more than 3,000 patents have been granted / filed related to cell encapsulation technologies, demonstrating the heightened pace of research in this domain
Foreseeing a lucrative future, several private and public investors have made capital investments worth approximately USD 1 billion, across over 100 funding instances, since 2013
Growth in partnership activity reflects the rising interest of stakeholders in this domain; over 70% of deals have been inked related to therapies for metabolic disorders, involving both international and indigenous parties
An evaluation of more than 300+ stakeholders engaged in cell therapies domain reveals the presence of several likely strategic partners spread across different geographical regions
The short term opportunity in this market is likely to be driven by licensing activity and will depend on the untapped potential of novel cell encapsulation technologies in different application areas
As multiple mid-late stage encapsulated cell therapies get commercialized in near future across different regions, the long term opportunity is likely to be distributed across diverse indications and encapsulation materials
The enormous potential of encapsulated cell-based therapies / devices in the treatment of chronic disorders has captured the interest of several stakeholders in the industry

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Table of Contents

PREFACE

1.1. Scope of the Report

1.2. Research Methodology

1.3. Chapter Outlines

EXECUTIVE SUMMARY

INTRODUCTION

3.1. Context and Background

3.2. An Overview of Cell Therapies

3.2.1. Cell Therapy Manufacturing

3.2.2. Supply Chain

3.2.3. Key Challenges

3.3. An Introduction to Cell Encapsulation

3.3.1. Historical Overview

3.3.2. Cell Encapsulation Approaches

3.3.3. Encapsulation Materials

3.3.4. Advantages and Challenges

3.4. Potential Applications of Cell Encapsulation

3.4.1. Targeted Drug / Therapy Delivery

3.4.2. Immunoprotection

3.4.3. Storage and Transportation

3.5. Key Growth Drivers and Road-blocks

CURRENT MARKET LANDSCAPE

4.1. Chapter Overview

4.2. Encapsulated Cell Therapies and Encapsulation Technologies: Developer Landscape

4.2.1. Distribution by Year of Establishment

4.2.2. Distribution by Geographical Location

4.2.3. Distribution by Size of Developers

4.2.4. Distribution by Type of Offering

4.3. Encapsulated Cell Therapies and Encapsulation Technologies: Development Pipeline

4.3.1. Distribution by Target Therapeutic Area

4.3.2. Distribution by Phase of Development

4.3.3. Distribution by Type of Cells and Other Encapsulated Components

4.3.4. Distribution by Type of Encapsulation Material Used

4.3.5. Distribution by Route of Administration

4.3.6. Distribution by Application Areas

4.4. Encapsulated Cell Therapies and Encapsulation Technologies: Initiatives of Big Pharmaceutical Players

ENCAPSULATED CELL THERAPIES AND ENCAPSULATION TECHNOLOGIES FOR METABOLIC DISORDERS: COMPANY PROFILES

5.1. Chapter Overview

5.2. Developers with Clinical Candidates

5.2.1. Beta-O2 Technologies

5.2.1.1. Company Overview

5.2.1.2. Financial Information

5.2.1.3. Product Description: ꞵAir Bio-artificial Pancreas

5.2.1.4. Recent Developments and Future Outlook

5.2.2. Diatranz Otsuka

5.2.2.1. Company Overview

5.2.2.2. Financial Information

5.2.2.3. Product Description: DIABECELL®

5.2.2.4. Recent Developments and Future Outlook

5.2.3. Sernova

5.2.3.1. Company Overview

5.2.3.2. Financial Information

5.2.3.3. Product Description: Cell Pouch System™

5.2.3.4. Recent Developments and Future Outlook

5.2.4. ViaCyte

5.2.4.1. Company Overview

5.2.4.2. Financial Information

5.2.4.3. Product Description: PEC-Direct™ and PEC-Encap™

5.2.4.4. Recent Developments and Future Outlook

5.3. Developers with Preclinical Candidates

5.3.1. ALTuCELL

5.3.2. Beta-Cell

5.3.3. Betalin Therapeutics

5.3.4. CellProtect Biotechnology

5.3.5. Defymed

5.3.6. Encellin

5.3.7. Kadimastem

5.3.8. PharmaCyte Biotech

5.3.9. Semma Therapeutics

5.3.10. Sigilon Therapeutics

5.3.11. Seraxis

5.3.12. SymbioCellTech

ENCAPSULATED CELL THERAPIES AND ENCAPSULATION TECHNOLOGIES FOR NON-METABOLIC DISORDERS: COMPANY PROFILES

6.1. Chapter Overview

6.2. Developers with Clinical Candidates

6.2.1. Azellon Cell Therapeutics

6.2.1.1. Company Overview

6.2.1.2. Financial Information

6.2.1.3. Product Description: Cell Bandage

6.2.1.4. Recent Developments and Future Outlook

6.2.2. EryDel

6.2.2.1. Company Overview

6.2.2.2. Financial Information

6.2.2.3. Product Description: EryDex System

6.2.2.4. Recent Developments and Future Outlook

6.2.3. Erytech Pharma

6.2.3.1. Company Overview

6.2.3.2. Financial Information

6.2.3.3. Product Description: GRASPA®

6.2.3.4. Recent Developments and Future Outloo

6.2.4. Gloriana Therapeutics

6.2.4.1. Company Overview

6.2.4.2. Financial Information

6.2.4.3. Product Description: EC-NGF

6.2.4.4. Recent Developments and Future Outlook

6.2.5. Living Cell Technologies

6.2.5.1. Company Overview

6.2.5.2. Financial Information

6.2.5.3. Product Description: NTCELL®

6.2.5.4. Recent Developments and Future Outlook

6.2.6. MaxiVAX

6.2.6.1. Company Overview

6.2.6.2. Financial Information

6.2.6.3. Product Description: MVX-ONCO-1

6.2.6.4. Recent Developments and Future Outlook

6.2.7. Neurotech Pharmaceuticals

6.2.7.1. Company Overview

6.2.7.2. Financial Information

6.2.7.3. Product Description: NT-501

6.2.7.4. Recent Developments and Future Outlook

6.2.8. PharmaCyte Biotech

6.2.8.1. Company Overview

6.2.8.2. Financial Information

6.2.8.3. Product Description: Cell-in-a-Box®

6.2.8.4. Recent Developments and Future Outlook

6.3. Developers with Preclinical Candidates

6.3.1. Beta-O2 Technologies

6.3.2. Sernova

6.3.3. Sigilon Therapeutics

PATENT ANALYSIS

7.1. Chapter Overview

7.2. Scope and Methodology

7.3. Encapsulated Cell Therapies and Encapsulation Technologies: Patent Analysis

7.3.1. Analysis by Publication Year

7.3.2. Analysis by Geographical Location

7.3.3. Analysis by CPC Classifications

7.3.4. Emerging Focus Areas

7.3.5. Leading Players: Analysis by Number of Patents

7.4. Encapsulated Cell Therapies and Encapsulation Technologies: Patent Benchmarking Analysis (Industry Players)

7.4.1. Analysis by Patent Characteristics

7.4.2. Analysis by Geographical Locatio

7.5. Encapsulated Cell Therapies and Encapsulation Technologies: Patent Valuation Analysis

7.6. Leading Patents: Analysis by Number of Citations

CLINICAL TRIAL ANALYSIS

8.1. Chapter Overview

8.2. Scope and Methodology

8.3. Encapsulated Cell Therapies and Encapsulation Technologies: List of Clinical Trials

8.3.1. Analysis by Trial Registration Year

8.3.2. Geographical Analysis by Number of Clinical Trials

8.3.3. Geographical Analysis by Enrolled Patient Population

8.3.4. Analysis by Phase of Development

8.3.5. Analysis by Study Design

8.3.6. Analysis by Type of Sponsor / Collaborator

8.3.7. Most Active Players: Analysis by Number of Registered Trials

8.3.8. Analysis by Trial Focus

8.3.9. Analysis by Therapeutic Area

8.3.10. Analysis by Clinical Endpoints

RECENT PARTNERSHIPS

9.1. Chapter Overview

9.2. Partnership Models

9.3. Encapsulated Cell Therapies and Encapsulation Technologies: Recent Collaborations and Partnerships

9.3.1. Analysis by Year of Partnership

9.3.2. Analysis by Type of Partnership

9.3.3. Analysis by Therapeutic Area

9.3.4. Analysis by Type of Cells and Other Encapsulated Components

9.3.5. Most Active Players: Analysis by Number of Partnerships

9.3.6. Analysis by Regions

9.3.6.1. Most Active Players

9.3.6.2. Intercontinental and Intracontinental Agreements

FUNDING AND INVESTMENT ANALYSIS

10.1. Chapter Overview

10.2. Types of Funding

10.3. Encapsulated Cell Therapies and Encapsulation Technologies: Recent Funding Instances

10.3.1. Analysis by Number of Funding Instances

10.3.2. Analysis by Amount Invested

10.3.3. Analysis by Type of Funding

10.3.4. Analysis by Number of Funding Instances and Amount Invested across Different Indications

10.3.5. Analysis by Amount Invested across Different Type of Cells and Other Encapsulated Components

10.3.6. Most Active Players: Analysis by Amount Invested

10.3.7. Most Active Investors: Analysis by Number of Instances

10.3.8. Geographical Analysis of Amount Invested

10.4. Concluding Remarks

GRANT ANALYSIS

11.1. Chapter Overview

11.2. Scope and Methodology

11.3. Encapsulated Cell Therapies and Encapsulation Technologies: List of Academic Grants

11.3.1. Analysis by Project Start Year

11.3.2. Analysis by Focus Area

11.3.3. Analysis by Support Period

11.3.4. Analysis by Type of Grant

11.3.5. Analysis by Amount Awarded

11.3.6. Analysis by Study Section

11.3.7. Analysis by Therapeutic Area

11.3.8. Analysis by Type of Cells and Other Encapsulated Components

11.3.9. Analysis by Type of Encapsulation Material

11.3.10. Leading Funding Institutes: Analysis by Number of Grants

11.3.11. Leading Recipient Organizations: Analysis by Number of Grants

POTENTIAL STRATEGIC PARTNERS

12.1. Chapter Overview

12.2. Scope and Methodology

12.3. Potential Strategic Partners for Cell Therapy Development

12.3.1. Opportunities in North America

12.3.1.1. Most Likely Partners for Cell Therapy Development

12.3.1.2. Likely Partners for Cell Therapy Development

12.3.1.3. Less Likely Partners for Cell Therapy Development

12.3.2. Opportunities in Europe

12.3.2.1. Most Likely Partners for Cell Therapy Development

12.3.2.2. Likely Partners for Cell Therapy Development

12.3.2.3. Less Likely Partners for Cell Therapy Development

12.3.3. Opportunities in Asia-Pacific and Rest of the World

12.3.3.1. Most Likely Partners for Cell Therapy Development

12.3.3.2. Likely Partners for Cell Therapy Development

12.3.3.3. Less Likely Partners for Cell Therapy Development

12.4. Potential Strategic Partners for Cell Therapy Manufacturing

12.4.1. Opportunities in North America

12.4.1.1. Most Likely Partners for Cell Therapy Manufacturing

12.4.1.2. Likely Partners for Cell Therapy Manufacturing

12.4.1.3. Less Likely Partners for Cell Therapy Manufacturing

12.4.2. Opportunities in Europe

12.4.2.1. Most Likely Partners for Cell Therapy Manufacturing

12.4.2.2. Likely Partners for Cell Therapy Manufacturing

12.4.2.3. Less Likely Partners for Cell Therapy Manufacturing

12.4.3. Opportunities in Asia-Pacific and Rest of the World

12.4.3.1. Most Likely Partners for Cell Therapy Manufacturing

12.4.3.2. Likely Partners for Cell Therapy Manufacturing

12.4.3.3. Less Likely Partners for Cell Therapy Manufacturing

MARKET FORECAST

13.1. Chapter Overview

13.2. Forecast Methodology and Key Assumptions

13.3. Overall Cell Encapsulation Technologies Market, 2019-2030

13.3.1. Cell Encapsulation Technologies Market by Upfront Payments, 2019-2030

13.3.2. Cell Encapsulation Technologies Market by Milestone Payments, 2019-2030

13.4. Overall Encapsulated Cell Therapies Market, till 2030

13.4.1. Encapsulated Cell Therapies Market: Distribution by Therapeutic Area

13.4.1.1. Encapsulated Cell Therapies Market for Eye Disorders, till 2030

13.4.1.2. Encapsulated Cell Therapies Market for Metabolic Disorders, till 2030

13.4.1.3. Encapsulated Cell Therapies Market for Neurological Disorders, till 2030

13.4.1.4. Encapsulated Cell Therapies Market for Oncological Disorders, till 2030

13.4.2. Encapsulated Cell Therapies Market: Distribution by Type of Encapsulation Material Used

13.4.2.1. Encapsulated Cell Therapies Market for Alginate-based Microcapsules, till 2030

13.4.2.2. Encapsulated Cell Therapies Market for Cellulose Hydrogels, till 2030

13.4.2.3. Encapsulated Cell Therapies Market for Medical-grade Plastics, till 2030

13.4.2.4. Encapsulated Cell Therapies Market for Red Blood Cells, till 2030

13.4.3. Encapsulated Cell Therapies Market: Distribution by Geography

13.4.3.1. Encapsulated Cell Therapies Market in North America, till 2030

13.4.3.2. Encapsulated Cell Therapies Market in Europe, till 2030

13.4.3.3. Encapsulated Cell Therapies Market in Asia-Pacific, till 2030

13.5. Encapsulated Cell Therapies for Eye Disorders: Distribution by Indication

13.5.1. Encapsulated Cell Therapies Market for Eye Disorders: Macular Telangectasia, till 2030

13.5.1.1. NT-501 (Neurotech Pharmaceuticals)

13.5.1.1.1. Target Patient Population

13.5.1.1.2. Sales Forecast

13.5.1.1.3. Geographical Distribution of Projected Opportunity

13.5.1.1.3.1. Projected Opportunity in the US

13.5.1.1.3.2. Projected Opportunity in EU5

13.5.1.1.3.3. Projected Opportunity in Rest of Europe

13.5.1.1.3.4. Projected Opportunity in Australia

13.5.2. Encapsulated Cell Therapies Market for Eye Disorders: Glaucoma, till 2030

13.5.2.1. NT-501 (Neurotech Pharmaceuticals)

13.5.2.1.1. Target Patient Population

13.5.2.1.2. Sales Forecast

13.5.2.1.3. Geographical Distribution of Projected Opportunity

13.5.2.1.3.1. Projected Opportunity in the US

13.5.2.1.3.2. Projected Opportunity in EU5

13.5.2.1.3.3. Projected Opportunity in Rest of Europe

13.5.2.1.3.4. Projected Opportunity in Australia

13.5.3. Encapsulated Cell Therapies Market for Eye Disorders: Retinitis Pigmentosa, till 2030

13.5.3.1. NT-501 (Neurotech Pharmaceuticals)

13.5.3.1.1. Target Patient Population

13.5.3.1.2. Sales Forecast

13.5.3.1.3. Geographical Distribution of Projected Opportunity

13.5.3.1.3.1. Projected Opportunity in the US

13.5.3.1.3.2. Projected Opportunity in EU5

13.5.3.1.3.3. Projected Opportunity in Rest of Europe

13.5.3.1.3.4. Projected Opportunity in Australia

13.6. Encapsulated Cell Therapies for Metabolic Disorders: Distribution by Indication

13.6.1. Encapsulated Cell Therapies Market for Metabolic Disorders: Type 1 Diabetes, till 2030

13.6.1.1. DIABECELL® (Diatranz Otsuka)

13.6.1.1.1. Target Patient Population

13.6.1.1.2. Sales Forecast

13.6.1.1.3. Geographical Distribution of Projected Opportunity

13.6.1.1.3.1. Projected Opportunity in the US

13.6.1.1.3.2. Projected Opportunity in Japan

13.6.1.1.3.3. Projected Opportunity in EU5

13.6.1.1.3.4. Projected Opportunity in Rest of Europe

13.6.1.1.3.5. Projected Opportunity in Australia

13.6.1.1.3.6. Projected Opportunity in New Zealand

13.7. Encapsulated Cell Therapies for Neurological Disorders: Distribution by Indication

13.7.1. Encapsulated Cell Therapies Market for Neurological Disorders: Ataxia Telangiectasia, till 2030

13.7.1.1. EryDex System (EryDel)

13.7.1.1.1. Target Patient Population

13.7.1.1.2. Sales Forecast

13.7.1.1.3. Geographical Distribution of Projected Opportunity

13.7.1.1.3.1. Projected Opportunity in EU5

13.7.1.1.3.2. Projected Opportunity in Rest of Europe

13.7.1.1.3.3. Projected Opportunity in the US

13.7.1.1.3.4. Projected Opportunity in Australia

13.7.1.1.3.5. Projected Opportunity in India

13.7.1.1.3.6. Projected Opportunity in Israel

13.7.1.1.3.7. Projected Opportunity in Tunisia

13.7.2. Encapsulated Cell Therapies Market for Neurological Disorders: Parkinson’s Disease, till 2030

13.7.2.1. NTCELL® (Living Cell Technologies)

13.7.2.2. Target Patient Population

13.7.2.2.1. Sales Forecast

13.7.2.2.2. Geographical Distribution of Projected Opportunity

13.7.2.2.2.1. Projected Opportunity in New Zealand

13.7.2.2.2.2. Projected Opportunity in the US

13.7.2.2.2.3. Projected Opportunity in Australia

13.7.2.2.2.4. Projected Opportunity in EU5

13.7.2.2.2.5. Projected Opportunity in Rest of Europe

13.8. Encapsulated Cell Therapies for Oncological Disorders: Distribution by Indication

13.8.1. Encapsulated Cell Therapies Market for Oncological Disorders: Pancreatic Cancer, till 2030

13.8.1.1. GRASPA® (Erytech Pharma)

13.8.1.1.1. Target Patient Population

13.8.1.1.2. Sales Forecast

13.8.1.1.3. Geographical Distribution of Projected Opportunity

13.8.1.1.3.1. Projected Opportunity in EU5

13.8.1.1.3.2. Projected Opportunity in Rest of Europe

13.8.1.1.3.3. Projected Opportunity in the US

13.8.2. Encapsulated Cell Therapies Market for Oncological Disorders: Non-Metastatic Pancreatic Cancer, till 2030

13.8.2.1. Cell-in-a-Box® (PharmaCyte Biotech)

13.8.2.1.1. Target Patient Population

13.8.2.1.2. Sales Forecast

13.8.2.1.3. Geographical Distribution of Projected Opportunity

13.8.2.1.3.1. Projected Opportunity in the US

13.8.2.1.3.2. Projected Opportunity in EU5

13.8.2.1.3.3. Projected Opportunity of Cell-in-a-Box in Rest of Europe

13.8.3. Encapsulated Cell Therapies Market for Oncological Disorders: Triple Negative Breast Cancer, till 2030

13.8.3.1. GRASPA (Erytech Pharma)

13.8.3.1.1. Target Patient Population

13.8.3.1.2. Sales Forecast

13.8.3.1.3. Geographical Distribution of Projected Opportunity

13.8.3.1.3.1. Projected Opportunity in EU5

13.8.3.1.3.2. Projected Opportunity in Rest of Europe

13.8.3.1.3.3. Projected Opportunity in the US

13.8.4. Encapsulated Cell Therapies Market for Oncological Disorders: Head and Neck Cancer, till 2030

13.8.4.1. MVX-ONCO-1 (MaxiVAX)

13.8.4.1.1. Target Patient Population

13.8.4.1.2. Sales Forecast

13.8.4.1.3. Geographical Distribution of Projected Opportunity

13.8.4.1.3.1. Projected Opportunity in EU5

13.8.4.1.3.2. Projected Opportunity in Rest of Europe

13.8.4.1.3.3. Projected Opportunity in the US

CONCLUSION

14.1. Cell-based Pharmacological Interventions are Characterized by Diverse Challenges, Most of which can be Mitigated using Various Encapsulation Strategies

14.2. The Pipeline Features Several Mid and Late Stage Encapsulated Therapy Products, Majority of which are intended for the Treatment of Metabolic Disorders

14.3. The Fragmented Developer Landscape Includes a Mix of Small and Mid-Sized Players; at Present, North America and Europe are Major Hubs of Development Activity

14.4. The Heightened Pace of Research in this Domain is Evident from the Rise in the Number of Patents Filed / Granted and the Clinical Studies Conducted in the Recent Years

14.5. Development Efforts in this Field have Drawn Significant Capital Investments from Private and Public Investors; this is Likely to Provide the Necessary Impetus to the Market’s Future Growth

14.6. Growth in Partnership Activity Reflects the Rising Interest of Industry Stakeholders; Most Agreements are Between Technology Providers and Cell Therapy Developers

14.7. Given the Increasing Number of Licensing Deals and the Expected Approval of Multiple Mid-Late Stage Candidates, the Market is Poised to Grow at a Significant Pace in the Coming Years